Do not take this medication with any of the following:
-Cisapride
-Dronedarone
-Metoclopramide
-Pimozide
-Thioridazine
This medication may also interact with the following:
-Alcohol
-Antihistamines for allergy, cough, and cold
-Certain antibiotics, such as gatifloxacin, moxifloxacin
-Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole
-Certain medications for irregular heartbeat, such as amiodarone, dofetilide, procainamide, quinidine, sotalol
-Certain medications for sleep or anxiety
-Certain medications for depression, such as amitriptyline, fluoxetine, paroxetine, sertraline
-Fluvoxamine
-General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol
-Levodopa or other medications for Parkinson disease
-Medications for blood pressure
-Medications for seizures
-Medications that relax muscles for surgery
-Opioid medications for pain
-Other medications that cause heart rhythm changes
-Phenothiazines, such as chlorpromazine, prochlorperazine
-Ziprasidone

They need to know if you have any of these conditions:
-Dementia
-Diabetes
-Have trouble controlling your muscles
-Heart disease
-High cholesterol
-History of breast cancer
-History of irregular heartbeat or rhythm
-History of stroke
-Liver disease
-Low blood cell levels (white cells, red cells, and platelets)
-Low blood pressure
-Parkinson disease
-Seizures
-Trouble swallowing
-An unusual or allergic reaction to asenapine, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breastfeeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. Do not stop taking except on your care team's advice. You may develop a severe reaction. Your care team will tell you how much medication to take.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.
This medication can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your care team right away.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original container. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.