Triprolidine Risks, Warnings, and Complications

Precautions Before Starting Triprolidine

Tell your healthcare professional if you have ever had an allergic reaction to triprolidine, any of the active or inactive ingredients in triprolidine formulations, other antihistamines, or any other drugs.

Give your healthcare professional a complete list of all your medicines, including prescription drugs, nonprescription drugs, vitamins, supplements, and herbal products. This can help avoid possible drug interactions.

Give your healthcare professional a complete medical history. Triprolidine may not be safe for people with a serious medical problem such as breathing problems, urination problems, eye problems (glaucoma), high blood pressure, heart disease, thyroid disease, liver disease, or stomach or intestinal problems.

If you are an older adult (age 65 years and above), talk to your doctor about other safer treatment options.

Tell your doctor if you are pregnant, could be pregnant, are planning a pregnancy or are breastfeeding. The medication passes into breast milk and large doses can potentially affect the infant and decrease milk supply.

Precautions During Use of Triprolidine

Keep all your medical and lab appointments. 

Triprolidine can make you drowsy and dizzy and cause blurry vision. Do not drive, operate machinery, or do anything else until you are fully alert and have clear vision. Remember that drinking alcohol can make these symptoms worse.

Triprolidine can cause a dry-up of body fluids. Drink water and enough fluids to stay well hydrated.

Get up slowly from a sitting or lying position to standing to avoid dizziness and falls.

Triprolidine may relieve allergy symptoms, but it will not cure your condition. If you continue having symptoms after 7 days of taking triprolidine, contact your healthcare provider.

Tell your doctors you are taking triprolidine before any surgery, including dental procedures. 

Tell lab personnel that you are on triprolidine, as it may lead to false test results with certain lab tests.

Contact your doctor if you become pregnant while taking triprolidine.

Triprolidine Drug Interactions

Triprolidine can have possible interactions with other drugs. This can affect how well the medications work. Interactions between triprolidine and other medicines can also increase the risk of severe adverse effects. Potential drug interactions of triprolidine include:

• Monoamine oxidase inhibitors (MAOIs) such as Nardil, Parnate, Marplan, Eldepryl, Carbex
• Barbiturates like phenobarbital
• Certain antidepressants and anxiety medications
• Antipsychotics
• Muscle relaxants
• Sleep aids
• Alcohol

Give your doctor or pharmacist a complete list of your medications, including prescription drugs, nonprescription (over-the-counter) drugs, dietary supplements, and herbal products. Also, tell your healthcare provider if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription medicines.