Do not take this medication with any of the following:
-Atazanavir
-Cidofovir
-Ketorolac
-Mavacamten
-Nelfinavir
-Rilpivirine
This medication may also interact with the following:
-Alcohol
-Aspirin and aspirin-like medications
-Certain antivirals for HIV or hepatitis
-Certain medications that treat or prevent blood clots, such as warfarin, clopidogrel, enoxaparin, dalteparin, apixaban, dabigatran, rivaroxaban
-Certain medications for blood pressure, heart disease, irregular heartbeat
-Certain medications for fungal infections, such as ketoconazole, itraconazole, posaconazole, voriconazole
-Cilostazol
-Cyclosporine
-Diazepam
-Digoxin
-Diuretics
-Erlotinib
-Iron salts
-Lithium
-Methotrexate
-Mycophenolate
-Other NSAIDs, medications for pain and inflammation, such as ibuprofen
-Pemetrexed
-Rifampin
-SNRIs, medications for depression, such as desvenlafaxine, duloxetine, levomilnacipran, venlafaxine
-SSRIs, medications for depression, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline
-St. John's Wort
-Steroid medications, such as prednisone or cortisone
-Tacrolimus

They need to know if you have any of these conditions:
-Bleeding disorder
-Coronary artery bypass graft (CABG) within the past 2 weeks
-Frequently drink alcohol
-Heart attack
-Heart disease
-Heart failure
-High blood pressure
-High levels of potassium in your blood
-Kidney disease
-Liver disease
-Low red blood cell levels
-Lung or breathing disease
-Receiving steroids, such as dexamethasone or prednisone
-Stomach bleeding
-Stomach or intestine problems
-Take medications that treat or prevent blood clots
-Tobacco use
-An unusual or allergic reaction to naproxen, esomeprazole, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
Do not take other medications that contain aspirin, ibuprofen, or naproxen with this medication. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many non-prescription medications contain aspirin, ibuprofen, or naproxen. Always read labels carefully.
This medication can cause serious ulcers and bleeding in the stomach. It can happen with no warning. Tobacco, alcohol, older age, and poor health can also increase risks. Call your care team right away if you have stomach pain or blood in your vomit or stool. This medication does not prevent a heart attack or stroke.
This medication may increase the chance of a heart attack or stroke. The chance may increase the longer you use this medication or if you have heart disease. If you take aspirin to prevent a heart attack or stroke, talk to your care team about using this medication.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.
Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medication.
Discuss this medication with your care team if you may be pregnant. Taking this medication after 20 weeks of pregnancy may cause serious birth defects. Use of this medication after 30 weeks of pregnancy is not recommended.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.