Do not take this medicine with any of the following medications:

-cisapride
-dronedarone
-flibanserin
-fluconazole
-lomitapide
-pimozide
-posaconazole
-saquinavir
-thioridazine
This medicine may also interact with the following medications:

-certain antiviral medicines for HIV or AIDS
-certain antibiotics like erythromycin and clarithromycin
-certain medicines for fungal infections like itraconazole, ketoconazole, and voriconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-dofetilide
-grapefruit juice
-midazolam
-narcotic medicines for pain
-other medicines that prolong the QT interval (cause an abnormal heart rhythm)
-rifampin
-St. John''s wort, Hypericum perforatum
-ziprasidone

They need to know if you have any of these conditions:

-heart disease
-irregular heartbeat or rhythm
-kidney disease
-liver disease
-lung disease
-vision problems
-an unusual or allergic reaction to crizotinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Tell your doctor about any unusual symptoms.
Tell your doctor or health care professional right away if you have any change in your eyesight. Do not drive or use machinery if you have a change in your eyesight.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body''s ability to fight infections. Try to avoid being around people who are sick.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
Women should not become pregnant while taking this medicine and for at least 45 days after the last dose. Men should use condoms during treatment and for at least 90 days after the last dose. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine and for 45 days after the last dose. This medicine may interfere with the ability to have a child. Talk with your doctor or health care professional if you are concerned about your fertility.

Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.