Lamotrigine

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Aug 02, 2023

Side Effects


Lamotrigine Side Effects

Possible side effects of lamotrigine are listed below. Call your doctor for medical advice if they are severe or persist after a few days.

  • Dizziness
  • Drowsiness
  • Headache
  • Vision changes (blurred vision, double vision)
  • Uncontrolled eye movements
  • Gastrointestinal symptoms such as heartburn, abdominal pain, nausea, vomiting, diarrhea, constipation, loss of appetite, weight loss
  • Balance or coordination difficulties
  • Uncontrolled shaking of the body
  • Problems with thinking, concentration, or speaking
  • Dry mouth
  • Runny nose
  • Back pain or joint pain
  • Missed periods or painful menstrual periods
  • Vaginal swelling, irritation, or itching

Lamotrigine can also cause more serious adverse reactions. Tell your doctor right away or seek emergency medical attention if you develop:

  • Swelling of the eyes, face, lips, tongue, or throat
  • Difficulty breathing or swallowing 
  • Hoarseness
  • Worsening seizures (longer lasting, more frequent, or different types of seizures than before)
  • Severe muscle pain and drowsiness
  • Fever, chills, headache, stiff neck, confusion, nausea, vomiting, light sensitivity, or unusual bruising or bleeding
  • Fever, skin rash, stomach pain, yellowing of the skin or eyes, swollen lymph glands, blood in urine, pain with urination, chest pain, muscle weakness, muscle pain, unusual bleeding or bruising, seizures, vision problems, trouble walking
  • Fever, chills, sore throat, cough, difficulty breathing, pink eye, ear pain, frequent urination, pain with urination, or other signs of infection
  • Fast or slow heartbeat, irregular heartbeat, shortness of breath, lightheadedness, or fainting 

The above list may not include all the potential side effects of lamotrigine. Contact your healthcare provider if your side effects are unusual or severe or do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Lamotrigine Overdose: In case of an overdose of lamotrigine, call your doctor immediately. You can also call your local poison control center, provincial poison control center, or the national poison control center at 1-800-222-1222. Call 911 or emergency services if a person has collapsed, cannot breathe, has had a seizure, or cannot be awakened. Signs and symptoms of an overdose may include irregular heartbeat, coordination, and balance problems, vision changes, uncontrolled eye movements, loss of consciousness, and coma.

Source: FDA